PRINCIPAL SCIENTIST/SR. SCIENTIST - PRODUCT SCIENCES
Company: Syncopation Life Sciences, Inc.
Location: San Mateo
Posted on: June 20, 2022
Job Description:
At Syncopation Life Sciences, upending the status quo is in our
DNA. We combine a deep understanding of CAR T resistance with a
vision of transforming peoples' lives through the development of
next generation cell therapies that provide deeper and more durable
responses to a growing number of patients.Syncopation is an
exciting biotechnology company founded by Crystal Mackall and
Robbie Majzner to develop next generation CAR T cell therapies
designed to achieve superior efficacy by pre-empting important
drivers of drug resistance. Our lead program includes a
differentiated and clinically validated CD22 CAR that is in
clinical development for patients with B-cell malignancies. To help
move this and other programs forward, Syncopation has brought
together a passionate and seasoned team to develop a focused
portfolio strategy. Our team is based in San Mateo, California.Join
us to help make a difference.POSITION SUMMARYSyncopation is hiring
a Principal Scientist/Sr. Scientist skilled in T cell immunology
and product characterization. The candidate will lead efforts to
identify critical quality attributes and conduct deeper analyses of
correlations with clinical biomarkers as well as manufacturing
process performance understanding.The successful candidate will
work closely with the Process Sciences team and the broader CMC
team to develop the cellular starting material and drug product
characterization strategies, supporting increased knowledge and
understanding of Syncopation's CAR-T products, as related to
phenotype, function, potency, and clinical outcomes. The role is
based in San Mateo, CA.WHAT YOU'LL DO AT SYNCOPATION
- Act as a leader and subject matter expert for cellular
immunology as a product characterization scientist within the
Process Sciences group
- Support product CQA correlative strategy in partnership with
Translational Sciences, Research, and Clinical; develop study and
data analysis plans with particular emphasis on supporting
transition into Phase 2/pivotal development
- Design and lead experiments to develop, qualify, and transfer
methods to external CDMOs/CROs
- Lead and facilitate assessment of CAR-T product
characterization, T cell fitness, and potency, including the
development and optimization of FIO in-process testing, evaluation
of donor starting material and drug substance and product
characterization
- Author analytical reports and support data packages for
regulatory submissions
- Collaborate closely with other key functions to enable complex
data/decisions within Process Sciences and cross functionally
- Effectively communicate data to internal stakeholders and
external partners
- Proactively enable cross-functional collaborations with
internal stakeholders, external partners, and consultants.
- Evaluate emerging technologies and platforms for application in
product pipeline developmentTHE RIGHT STUFFPREFERRED
QUALIFICATIONS:
- PhD in immunology, cell and molecular biology or related
field
- 8+ years of experience in a similar role in the biotechnology
industry; experience in the adoptive T-cell therapy field or
immuno-oncology will be essential
- Creative problem solver with deep T-cell biology experience and
the ability to apply new technologies/analytical tools for driving
deeper product understanding
- Experience with T-cell culture and cell-based assay
development, including potency, proliferation, exhaustion
- Multiparameter flow cytometry method design and demonstrated
application to interrogating phenotype of T-cell subsets and
relationship to function/potency
- Excellent organizational skills and an ability to effectively
prioritize work in a rapidly evolving landscape to deliver results
within established timelines
- Ability to work independently and as a part of teams across
multiple groups and in critical interactions with Analytical and
Process Development, Research, Translational, Clinical
- Experience supporting and authoring Regulatory submissions, as
well as generating data sets for inclusion in such submissions
- Experience in working with multidisciplinary teams. Experience
working in a small biotech/start up environment is a plus.
- Independently motivated, excel at driving execution, detail
oriented, creative approach to problem solving, and adept at
working in a fast-paced environment
- Must have interpersonal, organizational, written, and verbal
communication skills, and the ability to work collaboratively in a
team environmentEEO & EMPLOYMENT ELIGIBILITYSyncopation Life
Sciences, Inc. is committed to building a diverse, equitable, and
inclusive company. We provide equal opportunity in the terms and
conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Syncopation Life Sciences, Inc. also
complies with all applicable national, state and local laws
governing nondiscrimination in employment as well as work
authorization and employment eligibility verification requires of
applicable law.Syncopation Life Sciences requires all new hires to
be fully vaccinated against COVID-19 as of their start date. This
requirement is a condition of employment at Syncopation, and it
applies regardless of whether the position is located at a
Syncopation site or is fully remote. If you are unable to receive
the vaccine due to a disability or serious medical condition, or
because it is prohibited because of your sincerely held religious
beliefs, you will have an opportunity to request a reasonable
accommodation.
Keywords: Syncopation Life Sciences, Inc., San Mateo , PRINCIPAL SCIENTIST/SR. SCIENTIST - PRODUCT SCIENCES, Other , San Mateo, California
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