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Senior Research Associate I/II, Bioanalytical Sciences

Company: Soteria Biotherapeutics
Location: San Mateo
Posted on: June 24, 2022

Job Description:

Senior Research Associate I/II, Bioanalytical Sciences The Senior Research Associate I/II is a highly motivated scientist who will contribute to the advancement of drug candidates in the Soteria Biotherapeutics, Inc. oncology pipeline from discovery research to early development. He/she will use bench laboratory skills in analytical and bioanalytical chemistry, biochemistry, and/or molecular biology to execute a variety of standard and novel methods to support bioanalysis and bioassays as part of the product development pipeline at Soteria Biotherapeutics, Inc. and will utilize and maintain state-of-the-art analytical equipment. Key ResponsibilitiesThis individual will be responsible for implementation of analytical and bioanalytical assays in support of multiple areas of research and preclinical development, including Bioanalytical Sciences, CMC, and Protein Sciences. While studies in the labs are executed in a non-regulated non-GxP environment, high-quality standards are expected, and transfer of methods to partner labs is required. Bioanalytical methods may be used to quantitate therapeutic drug levels, detect and characterize immune responses evoked by drug candidates, measure biomarkers, and characterize drug candidates from buffered solution and various biological fluids and tissues. This individual will perform bioanalytical measurements, calculations, data entry, and lab notebook maintenance meticulously and with a high level of integrity. The candidate will contribute data to regulatory filings related to bioanalytical methods and characterization of drug candidates and their biological activities. Additionally, he/she will present data at weekly science meetings and maintain an open and collaborative relationship with peers.
Knowledge, Experience and Skills

  • A BS or MS in analytical chemistry, biochemistry, immunology, or cell biology or a related field with a minimum of 7 years for BS or 4 years for MS of relevant industry experience in bioanalytical aspects of biopharmaceutical development and analytical characterization of protein therapeutics.
  • Experience in ligand-based assays and protein quantitation bioassays (MSD, ELISA, Luminex, or Alphascreen) is required.
  • Experience with mass spectrometry, specifically intact mass, peptide mapping, and post-translational modification analysis is preferred. Experience with Thermo orbitrap instrumentation and BioPharma Finder software is desirable.
  • Experience with small molecule quantitation by LC-MS/MS is preferred.
  • This individual must have excellent interpersonal and both oral and written communication skills along. Method development experience is required.
  • Experience in immuno-oncology drug development (both small molecule and biologics) is highly desired.
  • Experience in method transfer to contract labs is beneficial.
  • Works well in a small, highly collaborative team setting.
  • Can meet deadlines in a fast-paced work environment.

Keywords: Soteria Biotherapeutics, San Mateo , Senior Research Associate I/II, Bioanalytical Sciences, Other , San Mateo, California

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