Senior Research Associate I/II, Bioanalytical Sciences
Company: Soteria Biotherapeutics
Location: San Mateo
Posted on: June 24, 2022
Senior Research Associate I/II, Bioanalytical Sciences The
Senior Research Associate I/II is a highly motivated scientist who
will contribute to the advancement of drug candidates in the
Soteria Biotherapeutics, Inc. oncology pipeline from discovery
research to early development. He/she will use bench laboratory
skills in analytical and bioanalytical chemistry, biochemistry,
and/or molecular biology to execute a variety of standard and novel
methods to support bioanalysis and bioassays as part of the product
development pipeline at Soteria Biotherapeutics, Inc. and will
utilize and maintain state-of-the-art analytical equipment. Key
ResponsibilitiesThis individual will be responsible for
implementation of analytical and bioanalytical assays in support of
multiple areas of research and preclinical development, including
Bioanalytical Sciences, CMC, and Protein Sciences. While studies in
the labs are executed in a non-regulated non-GxP environment,
high-quality standards are expected, and transfer of methods to
partner labs is required. Bioanalytical methods may be used to
quantitate therapeutic drug levels, detect and characterize immune
responses evoked by drug candidates, measure biomarkers, and
characterize drug candidates from buffered solution and various
biological fluids and tissues. This individual will perform
bioanalytical measurements, calculations, data entry, and lab
notebook maintenance meticulously and with a high level of
integrity. The candidate will contribute data to regulatory filings
related to bioanalytical methods and characterization of drug
candidates and their biological activities. Additionally, he/she
will present data at weekly science meetings and maintain an open
and collaborative relationship with peers.
Knowledge, Experience and Skills
- A BS or MS in analytical chemistry, biochemistry, immunology,
or cell biology or a related field with a minimum of 7 years for BS
or 4 years for MS of relevant industry experience in bioanalytical
aspects of biopharmaceutical development and analytical
characterization of protein therapeutics.
- Experience in ligand-based assays and protein quantitation
bioassays (MSD, ELISA, Luminex, or Alphascreen) is required.
- Experience with mass spectrometry, specifically intact mass,
peptide mapping, and post-translational modification analysis is
preferred. Experience with Thermo orbitrap instrumentation and
BioPharma Finder software is desirable.
- Experience with small molecule quantitation by LC-MS/MS is
- This individual must have excellent interpersonal and both oral
and written communication skills along. Method development
experience is required.
- Experience in immuno-oncology drug development (both small
molecule and biologics) is highly desired.
- Experience in method transfer to contract labs is
- Works well in a small, highly collaborative team setting.
- Can meet deadlines in a fast-paced work environment.
Keywords: Soteria Biotherapeutics, San Mateo , Senior Research Associate I/II, Bioanalytical Sciences, Other , San Mateo, California
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