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Sr. Research Scientist II, Protein Biochemistry

Company: Gilead Sciences, Inc.
Location: San Mateo
Posted on: January 15, 2023

Job Description:

Sr. Research Scientist II, Protein BiochemistryUnited States - California - Foster CityGilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.Making an impact on a global scaleInclusion is one of the company's five core values. That's because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide. When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly For Current Gilead Employees and Contractors:Please log onto your Internal Career Site to apply for this job.Job DescriptionThe Protein Therapeutics Department in Gilead is looking for a Senior Research Scientist II to help support and expand our protein sciences capabilities. The candidate will join the Protein biochemistry group delivering high-quality recombinant proteins to fulfill the needs of teams focused on creating new therapies in Immunology, Oncology, and Virology.The ideal candidate has demonstrated expertise in leading multiple protein generation projects to enable small-molecule and large-molecule campaigns. On the technical side, he/she will design constructs required to address the protein needs for biochemical and biophysical assays, including high throughput screening and structure determination via crystallography and Cryo-EM. Proven experience with small-scale expression testing and optimization in multiple hosts (E. coli, insect, and mammalian cells) for intracellular and secreted proteins is a must. The candidate will use milligram scale expression, purification process development, optimization, and solid protein analytics skills to deliver fit-for-purpose proteins. Experience with producing challenging proteins is desired (highly disordered, low expression yield, aggregation-prone, membrane-bound proteins).Additional responsibilities for this role include managing, training, and mentoring junior and senior scientists to fulfill project needs by delivering high-quality proteins on time.The candidate will interact closely and collaborate across all functions of Drug Discovery -Biology, Biologics Discovery, Structural and Computational Biology, and Biophysical and Biochemical Assay within Gilead. In addition, the scientist will be expected to help build protein generation capacity and capabilities by managing and establishing collaborations with CROs and academic laboratories.The position will require the scientist to work creatively, collaboratively, and in a fast-paced environment. He/she will also be encouraged to test and implement new technologies that further enhance the capabilities of the Protein Biochemistry team or address specific challenges in protein generation.Education and Technical Skills:

  • Ph.D. with 5+ years of Biochemistry research experience, including 5+ years in Protein Sciences in an industry setting.
  • A proven track record of independently producing quality proteins from several expression hosts (mammalian, insect, and bacterial cells) is required.
  • Training in classical protein production processes and techniques (Molecular Biology, small-scale expression, and purification, affinity capture, ion exchange, size exclusion chromatography using AKTA chromatographic instruments, large-scale protein purification process development and optimization (milligrams
  • Expert knowledge of protein sciences analytics (sequence alignment, protein structure analysis using modeling software, SDS PAGE analysis, Western blot, FPLC and HPLC, DLS, DSF, Mass Spectrometry)
  • Experience building and managing a protein sciences team and laboratory is strongly desired.
  • Ability to establish and foster productive collaborations with internal and external partners, including academic labs and CROs, is required.
  • Excellent communication and presentation skills; works independently and as a team player.
  • Attention to detail, accurate record keeping, and good lab citizenship practices are essential.For jobs in the United States:As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S., Canada, Australia, Singapore, and Hong Kong employees and contractors to receive the COVID-19 vaccines as a condition of employment. "Full vaccination" is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT PAY TRANSPARENCY NONDISCRIMINATION PROVISION Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.For Current Gilead Employees and Contractors:Please log onto your Internal Career Site to apply for this job.

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Keywords: Gilead Sciences, Inc., San Mateo , Sr. Research Scientist II, Protein Biochemistry, Other , San Mateo, California

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