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Research Scientist, Drug Metabolism and Pharmacokinetics

Company: Gilead Sciences, Inc.
Location: San Mateo
Posted on: January 25, 2023

Job Description:

Research Scientist, Drug Metabolism and PharmacokineticsUnited States - California - Foster CityGilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.Making an impact on a global scaleInclusion is one of the company's five core values. That's because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide. When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly For Current Gilead Employees and Contractors:Please log onto your Internal Career Site to apply for this job.Job DescriptionGilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/ AIDS, liver diseases, oncology and inflammation, serious respiratory and cardiovascular conditions, headquartered in Foster City, California. As a Research Scientist, you will join the Drug Metabolism & Pharmacokinetics (DMPK) group in research, working closely with biology, protein biochemistry, toxicology, clinical pharmacology, pharmaceutical sciences, and regulatory to optimize leads, to select drug candidates for clinical evaluation, and contribute to IND/ IMPD and NDA/ BLA filings.The primary responsibilities of this position will be to provide ADME/PK assessment, modeling and simulation, and project representation to support discovery and development teams.Job Responsibilities:

  • Serve as DMPK subject matter expert on dynamic cross-functional teams, conduct PK and PBPK analysis, and human efficacious dose prediction, provide in vitro and in vivo ADME/PK and drug-drug interaction (DDI) data, interpretation and presentations to teams.
  • Work closely with project teams, line management, internal and external resources to assure high quality and timely delivery of drug candidate, documentations for regulatory submissions and regulatory response.
  • Problem-solving ability applying PK, metabolizing enzyme, and transporter knowledge to mitigate project issues
  • Communicate and educate others on areas of ADME science as a technical expert.
  • Makes major contributions to scientific literature and conferences through publication and presentation of research results.Knowledge, Experience and Skills:
    • Highly motivated individual with a Ph.D. in pharmaceutical sciences related fields.
    • Prior experience and sound knowledge in PK, PK/PD principles, drug metabolism, and transporter are preferred.
    • The candidate will possess strong work ethics, ability to work independently in a focused, goal-oriented manner. The ability to interact and collaborate with scientists from various disciplines and functional areas is vital to this role.
    • The candidate will be able to seek evidence of productivity and independence through authorship of research in peer-reviewed publications.
    • Excellent interpersonal, written and oral communication skills are prerequisites to perform in a highly-matrixed team environment.For jobs in the United States:As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S., Canada, Australia, Singapore, and Hong Kong employees and contractors to receive the COVID-19 vaccines as a condition of employment. "Full vaccination" is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT PAY TRANSPARENCY NONDISCRIMINATION PROVISION Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.For Current Gilead Employees and Contractors:Please log onto your Internal Career Site to apply for this job.

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Keywords: Gilead Sciences, Inc., San Mateo , Research Scientist, Drug Metabolism and Pharmacokinetics, Other , San Mateo, California

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