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PRINCIPAL SCIENTIST/SR. SCIENTIST - PRODUCT SCIENCES

Company: CARGO-Therapeutics
Location: San Mateo
Posted on: January 25, 2023

Job Description:


POSITION SUMMARYCARGO Therapeutics is hiring a Principal Scientist/Sr. Scientist skilled in T cell immunology and product characterization. The candidate will lead efforts to identify critical quality attributes and conduct deeper analyses of correlations with clinical biomarkers as well as manufacturing process performance understanding.The successful candidate will work closely with the Process Sciences team and the broader CMC team to develop the cellular starting material and drug product characterization strategies, supporting increased knowledge and understanding of CARGO's CAR-T products as related to phenotype, function, potency, and clinical outcomes. The role is based in San Mateo, CA.WHAT YOU'LL DO AT CARGO

  • Act as a leader and subject matter expert for cellular immunology as a product characterization scientist within the Process Sciences group
  • Support product CQA correlative strategy in partnership with Translational Sciences, Research, and Clinical; develop study and data analysis plans with particular emphasis on supporting transition into Phase 2/pivotal development
  • Design and lead experiments to develop, qualify, and transfer methods to external CDMOs/CROs
  • Lead and facilitate assessment of CAR-T product characterization, T cell fitness, and potency, including the development and optimization of FIO in-process testing, evaluation of donor starting material and drug substance and product characterization
  • Author analytical reports and support data packages for regulatory submissions
  • Collaborate closely with other key functions to enable complex data/decisions within Process Sciences and cross-functionally
  • Effectively communicate data to internal stakeholders and external partners
  • Proactively enable cross-functional collaborations with internal stakeholders, external partners, and consultants.
  • Evaluate emerging technologies and platforms for application in product pipeline developmentTHE RIGHT STUFFPREFERRED QUALIFICATIONS:
    • PhD in immunology, cell and molecular biology or related field
    • 8+ years of experience in a similar role in the biotechnology industry; experience in the adoptive T-cell therapy field or immuno-oncology will be essential
    • Creative problem solver with deep T-cell biology experience and the ability to apply new technologies/analytical tools for driving deeper product understanding
    • Experience with T-cell culture and cell-based assay development, including potency, proliferation, exhaustion
    • Multiparameter flow cytometry method design and demonstrated application to interrogating phenotype of T-cell subsets and relationship to function/potency
    • Excellent organizational skills and an ability to effectively prioritize work in a rapidly evolving landscape to deliver results within established timelines
    • Ability to work independently and as a part of teams across multiple groups and in critical interactions with Analytical and Process Development, Research, Translational, Clinical
    • Experience supporting and authoring Regulatory submissions, as well as generating data sets for inclusion in such submissions
    • Experience in working with multidisciplinary teams. Experience working in a small biotech/start up environment is a plus.
    • Independently motivated, excel at driving execution, detail oriented, creative approach to problem solving, and adept at working in a fast-paced environment
    • Must have interpersonal, organizational, written, and verbal communication skills, and the ability to work collaboratively in a team environmentABOUT CARGOCARGO Therapeutics, formerly Syncopation Life Sciences, is advancing a new generation of adoptive cell therapies for cancers. Our cell therapies focus on addressing the primary mechanisms of failure, or resistance and relapse, to the currently available Chimeric Antigen Receptor T-cell (CAR T) therapies. Despite the advances made by existing autologous CAR T therapies, these treatments are only curative for less than half of all cancer patients, and therapeutic failure, resistance, and relapse are common. In addition, far too many patients are unable to access these -potentially curative therapies due to barriers, including manufacturing, supply, -time, -and reimbursement challenges.CARGO is actively working to address these barriers with novel solutions that address the problems of resistance and access. Through smarter science, CARGO is developing and delivering CAR T-cell therapies to cure more patients. Focused on the delivery of complex therapeutic cargo, we enable the -multiplex -engineering necessary to overcome multiple mechanisms of tumor resistance, to counter inhibition by solid tumors, and in the allogeneic setting to evade immune rejection. -From research to manufacturing to clinical care, we at CARGO aspire to disrupt the status quo to overcome resistance and maximize access to -curative therapeutics.
      Join us to help make a difference.CARGO Therapeutics is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. CARGO Therapeutic also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of applicable law.CARGO Therapeutics requires all new hires to be fully vaccinated against COVID-19 as of their start date. - This requirement is a condition of employment at CARGO, and it applies regardless of whether the position is located at a CARGO site or is fully remote. - If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

Keywords: CARGO-Therapeutics, San Mateo , PRINCIPAL SCIENTIST/SR. SCIENTIST - PRODUCT SCIENCES, Other , San Mateo, California

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