Protein Scientist (Expression)

Company: BigHat Biosciences
Location: San Mateo
Posted on: January 25, 2023

Job Description:

The Role: BigHat Biosciences is looking for a motivated and energetic Protein Scientist with a strong background in cell-based protein expression to further advance BigHat's platform for ML-driven antibody discovery and engineering.*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate. The Role: BigHat Biosciences is looking for a motivated and energetic Protein Scientist with a strong background in cell-based protein expression to further advance BigHat's platform for ML-driven antibody discovery and engineering.

* At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.

Key Responsibilities

* Onboard protein expression using transient transfections in Expi293 and/or ExpiCHO cells at 5 mL to 1 L scales
* Design, develop, and execute production workflows for molecule design, plasmid construction, expression, titering, and harvest
* Expression of antigens and various antibody formats, including fragments, IgGs, novel fusion proteins, and bi- and multi-specifics
* Evaluation and incorporation of emerging technologies for higher expression, increased speed, and/or decreased COGs
* Work collaboratively with cross-functional internal teams and external service providers to ensure timely completion of deliverables

Preferred Qualifications

* Ph.D and at least one (1) year of hands-on working experience related to protein expression, preferably with antibody molecules using Expi293 or ExpiCHO cells
* A strong molecular biology background for developing efficient cloning workflows
* Prior innovation in mammalian expression for increasing yield, speed, or throughput
* Appetite for learning and using new tools and technologies to support core responsibilities and cross-functional communication
* A strong can-do mentality and desire to thrive in a dynamic start-up environment
* Nice-to-haves include experience in protein purification, analytics, or automation

Keywords: BigHat Biosciences, San Mateo , Protein Scientist (Expression), Other , San Mateo, California