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Principal Scientist, Translational Medicine

Location: San Mateo
Posted on: November 15, 2023

Job Description:

Principal Scientist, Translational Medicine at CARGO Therapeutics Reporting to an Associate Director, thePrincipal Scientist, Translational Medicinewill be responsible for aiding in the design and implementation of the translational plan in support of CARGO's CAR T pipeline, and aid in reverse translational initiatives. The successful candidate will oversee and conduct laboratory activities related to ongoing and future cell therapy clinical studies. The individual will be lab-based and work in a dynamic team-based environment. The ideal candidate will have a working knowledge of clinical trial implementation, bioanalytical method development, method qualification and execution in support of a clinical study including analyzing data under GCLP guidelines and reporting results per data transfer specifications. The ideal candidate will have experience in flow cytometry, ddPCR, MSD, and ELISA platforms, and possess strong and demonstrated documentation skills. The role is based in San Mateo, CA. WHAT YOU'LL DO AT CARGO THERAPEUTICS

  • Serve as a Translational Medicine (TM) Clinical Program Lead and oversee clinical pharmacology and biomarker plan development and execution
  • Oversee delivery of key clinical pharmacology data generated at both external contract research organizations (CROs) and the internal CARGO TM lab
  • Guide development, qualification, and implementation of novel assays for clinical biospecimen monitoring and biomarker discovery
  • Oversee and perform laboratory activities related to TM scientific deliverables
  • Work with Clinical Data Management and Data Sciences to qualify data acquisition and interpretation of translational data
  • Write, review, and edit technical documents including SOPs, development/qualification plans and reports, and drafting of study reports
  • Establish relationships with CRO and support the transfer of novel methods
  • Support the preparation of data packages for publication, presentation and/or submission to Regulatory agencies
  • Support Regulatory activities and requests including Investigational New Drug (IND), Biologics License Application (BLA), and other key global Regulatory filings
  • Contribute to internal and external scientific discussions
  • Other duties as applicable THE RIGHT STUFF: Required Experience & Qualifications
    • Doctorate or Master's degree in a scientific discipline, preferably in Immunology or Molecular Biology
    • 8+ years' cell therapy, immunology, or cancer biology experience
    • Familiarity in the areas of cell therapy, immunology, immuno-oncology and cancer biology
    • Understanding of CAR T-cell clinical pharmacology studies (ie: pharmacokinetics and pharmacodynamics)
    • Experience with clinical biospecimen testing, assay development, and bioanalytical method qualification
    • Experience withflow cytometry,ddPCR, MSD, and ELISA platforms
    • Knowledge of Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN)
    • Self-motivated and enthusiastic person with an attention for detail
    • Strong critical thinking, analytical and problem-solving skills, and ability to think creatively
    • Excellent verbal and written communication skills
    • Comfortable in a start-up environment and able to adapt to changing priorities
    • Able to work effectively in a team setting and enjoy collaboration with others
    • Prior supervisory experience is preferred Preferred Skills & Qualifications If you are an experienced Principal Scientist with a strong background in clinical translational research and possess a keen eye for experimental detail, we encourage you to apply for this exciting opportunity. The ideal candidate should have experience developing, qualifying, and implementing assays for clinical biospecimen monitoring utilizing flow cytometry, ddPCR, MSD, and ELISA platforms. PAY RANGE The combined pay range for this role is $148,000 - $200,000. Title and salary will be based on our assessment of skills and experience relevant to our needs for the role. ABOUT CARGO THERAPEUTICS CARGO Therapeutics is engineering best-in-class CAR T-cell therapy to overcome resistance to cancer treatment and address barriers to access so that more patients may benefit from potentially curative therapies. CARGO is on a mission to outsmart cancer by advancing a new generation of best-in-class chimeric antigen receptor (CAR) T-cell therapies. Despite advances made by commercially available autologous CARs, these treatments are curative for fewer than half of all cancer patients. In addition, far too many patients are unable to access these potentially curative therapies due to other challenges, including manufacturing, supply constraints, slow turnaround time and reimbursement hurdles. The team at CARGO is intensely focused on pursuing novel solutions to achieve better cancer treatment outcomes and experiences. Our founders are pioneers and world experts in CAR T-cell therapy, and we have built a team with experience and success developing, manufacturing, launching and commercializing oncology and cell therapy products. CARGO Therapeutics colleagues share a passion to help others thrive. We are tenacious in the relentless pursuit of our mission, and we innovate to change the game for the patients we serve. Join us to help make a difference! EEO & EMPLOYMENT ELIGIBILITY CARGO Therapeutics, Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status. CARGO Therapeutics, Inc. also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification required of applicable law. CARGO Therapeutics requires all new hires to be fully vaccinated against COVID-19 as of their start date.This requirement is a condition of employment at CARGO Therapeutics, and it applies regardless of whether the position is located at a CARGO Therapeutics site or is fully remote.If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation. J-18808-Ljbffr

Keywords: THIRD ROCK VENTURES, LLC, San Mateo , Principal Scientist, Translational Medicine, Other , San Mateo, California

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